Dr. John Lau Sie Yon

John Lau 150

Dr. John Lau Sie Yon

Ph.D, B. Eng (Hons)
Senior Lecturer of Chemical Engineering
Program Coordinator of Environmental Engineering Programme

Contact Details

Telephone: +60 85 443939 Ext 2418
Location: Skylark 3 Room 454
Email: johnlsy@curtin.edu.my


Dr. John Lau is currently a senior lecturer in the Chemical Engineering department, Programme Coordinator for Environmental Engineering and leading Biotechnology Research Cluster in Faculty of Engineering and Science, Curtin University Malaysia. He accomplished his Bachelor degree in Chemical Engineering in Universiti Sains Malaysia (USM), Penang in 2008. He then pursued his postgraduate studies at USM in 2009 and graduated in 2013. During his PhD studies, he had served as a research engineer and involved in designing a pilot-scale pharmaceutical production plant, which was funded by the Malaysian Technology Development Corporation (MTDC). Then, he was offered to join a Malaysia-Cuba technology transfer project at Finlay Institute, Cuba in 2012. His areas of specialization in bioprocess engineering include enzymatic reaction and application, Aptamer mediated biosensing, nanovehicle in drug delivery as well as bioremediation of wastewater.

Academic History

  • PhD in Chemical Engineering, Universiti Sains Malaysia (USM), 2009-2013
  • BEng (Hons.) in Chemical Engineering, Universiti Sains Malaysia (USM), 2004-2008


  • PECIPTA 2017, Bronze Award
  • USM research publication Awards, 2011 and 2012
  • MyBrain 15(MyPhd) Scholarships Award, 2011
  • USM-Postgraduate Research Grant Award, 2010

Research Interest

  • Enzyme technology for various applications
  • Biocatalysis development for the production of fine chemicals\
  • Membrane separation processes
  • Chiral separations using enzymatic membrane reactor
  • Biomass conversion for industry applications
  • Aptamer mediated biosensor for pathogen detection
  • Nano-vehicles for targeted drug delivery

Selected Research Funding & Research Projects

  1. One-Stop Protein Information Portal to simplify information retrieval by integrating diverse proteomic data. PRGS. (2015-2018). Co-investigator
  2. Investigation on shear strength and consolidation behaviour of peat treated using microbial induced calcite precipitation. FRGS. (2015-2018). Co-investigator
  3. Enzyme-immobilised polymeric capsules for continuous palm oil mill effluent (POME) treatment. Curtin Sarawak Research Institute CSM Academic Grants. (2013-2015)- Principal investigator
  4. Kinetic modelling of aptameric sensing for real-time pathogen detection and bio-screening. FRGS grant. (2014-2017) Principle-investigator
  5. Advancing pathogen detection and screening using aptameric molecules (2014-2016). Curtin Research Flagship Programme. Principle-investigator

Book chapter

  1. H. Kamaruddin, M.H. Uzir, F.N. Gonawan, and S.Y. Lau.(2015) Chapter 16: Dynamic Enzymatic Kinetic Resolution of NSAIDS. Nanobiomaterials in Antimicrobial Therapy. Advances in Bioprocess Technology,Spinger int, Page 317-356.
  2. Tiong Chiong, Caleb Acquah, Sie Y. Lau, Ee H. Khor, Michael K. Danquah. (2016).Chapter 12: Microalgal-Based Protein By-Products: Extraction, Purification, and Applications. Protein Byproducts: Transformation from Environmental Burden into Value-Added Products. Elsevier Science and Technology. Pages 213-234

Journal Publication

  1. Lau Yien Jun, N.M. Mubarak, Min Juey Yee, Lau Sie Yon, Chua Han Bing, Mohammad Khalid, E.C. Abdullah. An overview of functionalised carbon nanomaterial for organic pollutant removal. ( in press)
  2. Vanitha Katheresan, Jibrail Kansedo, Sie Yon Lau. Efficiency of Various Recent Wastewater Dye Removal Methods: A Review. Journal of Environmental Chemical Engineering. https://doi.org/10.1016/j.jece.2018.06.060. (Available online 26 June 2018).
  3. Caleb Acquah, Michael K. Danquah, Yi Wei Chan, Charles K. S. Moy, Clarence M. Ongkudon & Sie Yon Lau. (2018) Chromatographic characterisation of aptamer-modified poly(EDMA-co-GMA) monolithic disk format for protein binding and separation, Separation Science and Technology, DOI: 10.1080/01496395.2018.1443139.
  4. Tan KX, Lau SY, Danquah MK. (2018). Process evaluation and in vitro selectivity analysis of aptamer-drug polymeric formulation for targeted pharmaceutical delivery. 101:996-1002. doi: 10.1016/j.biopha.2018.03.052
  5. Phang, RKI, Chan, YS., Wong, KS., Lau, SY. (2018). Isolation and Characterisation of Urease-producing Bacteria from Tropical Peat. Biocatalysis and Agricultural Biotechnology. Volume 13, 168-175
  6. Tan, K. X., Danquah, M. K., Sidhu, A., Lau, S. Y. and Ongkudon, C. M. (2017), Biophysical characterization of layer-by-layer synthesis of aptamer-drug microparticles for enhanced cell targeting. Biotechnol Progress. doi:10.1002/btpr.2524.
  7. Tan KX, Danquah MK, Sidhu A, Lau SY, Ongkudon CM. (2016 ). Aptamer-mediated polymeric vehicles for enhanced cell-targeted drug delivery. Current Drug Targets. 17 (16), 1-11.
  8. Tan KX, Danquah MK, Sidhu A, Ongkudon CM, Lau SY. (2016). Towards targeted cancer therapy: Aptamer or oncolytic virus? European Journal of Parhameutical Science, 96, 8-19.
  9. C Acquah, LS Yon, Z Tuah, NL Ngee, MK Danquah. (2016). Synthesis and performance analysis of oil palm ash (OPA) based adsorbent as a palm oil bleaching material. Journal of Cleaner Production 139, 1098-1104.
  10. Tung Chiong, Sie Yon Lau, Zhan Hong Lek, Yew Koh Boon, Michael K. Danquah, Enzymatic treatment of methyl orange dye in synthetic wastewater by plant-based peroxidase enzymes, (2016). Journal of Environmental Chemical Engineering. ISSN 2213-3437, http://dx.doi.org/10.1016/j.jece.2016.04.030.
  11. Tan SY, Acquah C, Sidhu A, Ongkudon CM, Yon L S, Danquah MK. SELEX modifications and bioanalytical techniques for aptamer-target binding characterization. (2016). Crit Rev Anal Chem. 15:0. (Published)
  12. Caleb Acquah, Michael Danquah, John L Yon, Amandeep Sidhu, Clarence M Ongkudon. A review on immobilised aptamers for high throughput biomolecular detection and screening. (2015). Analytica Chimica Acta. 888, Pages 10–18
  13. Chiong T, Lau SY, Khor EH, Danquah MK. (2014). Enzymatic approach to phenol removal from wastewater using peroxidases. OA Biotechnology. 10;3(1):9.
  14. N. Gonawan, Lau S. Y., Kamaruddin A. H., and Uzir M. H.(2014). Rapid Base-Catalyzed Racemization of (R)-Ibuprofen Ester in Isooctane–Dimethyl Sulfoxide Medium with Improved Kinetic Model. Industrial & Engineering Chemistry Research . 53 (2), 635-642.
  15. Lau, S. Y., Gonawan, F. N., Kamaruddin, A. H., Uzir, M. H. (2013). Enzymatic Deracemization of (R,S)-Ibuprofen Ester via Lipase-Catalyzed Membrane Reactor. Industrial & Engineering Chemistry Research. 52 (27), pp 9441–9453
  16. Gonawan, F. N, Lau, S. Y., Kamaruddin, A. H. and Uzir, M. H. (2012). Effect of Co-solvent addition on the reaction kinetics of the lipase catalyzed resolution of ibuprofen ester. Journal of Chemical Technology & Biotechnology. 88(4),672-679.
  17. Lau, S. Y., Gonawan, F. N., Bhatia, S., Kamaruddin, A. H., & Uzir, M. H. (2011). Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology. Chemical Engineering Journal, 166(2), 726-737.
  18. Lau, S.Y., Uzir, M.H., Kamaruddin, A.H. and Bhatia, S. (2010). Lipase-catalyzed dynamic kinetic resolution of racemic ibuprofen ester via hollow fiber membrane reactor: Modeling and simulation. Journal of Membrane Science, 357(1-2), 109-121.

Conference Papers

  1. Lau, S.Y., Mohamad, H. U., and Azlina, H.K. (2012). Production of optically pure (S)-ibuprofen acid via enzymatic dynamic kinetic resolution in hollow fiber membrane reactor. Chemeca 2012, Wellington, New Zealand.
  2. Lau, S.Y., Bhatia, S., Uzir, M.H., and Kamaruddin, A.H. (2010). Enantioseparation of (R,S)-ibuprofen ester via lipase-catalyzed dynamic kinetic resolution in a hollow fiber membrane reactor. 13th Asia Pacific Confederation of Chemical Engineering Congress (APCChe 2010): Innovation and Sustainability in New Chemical Engineering Era, 2010, Taipei, Taiwan.
  3. Lau, S.Y., Bhatia, S., Uzir, M.H., and Kamaruddin, A.H. (2009). Review: Progress of Dynamic Kinetic Resolution in Production of Chiral Compound. Chemical Engineering Colloquium,2009: Synergizing Innovation, Think Beyond Sustainable Future, 2009, Penang, Malaysia.

HDR Supervision

  1. HDR Student Name: Sheena  Lau Yien Jun (PhD)
    Supervisor: Dr John Lau Sie Yon, Dr. Mubarak Mujawar, Dr. Chua Han Bing
    Project: Immobilised Enzyme on Bulky paper for continuous Dye wastewater removal.
    Status: On-going
  2. HDR Student Name: Evelyn Chiong Tung (PhD)
    Supervisor: Dr John Lau Sie Yon, Professor Dr Michael Danquah,  Dr. Khor Ee Huey
    Project: Phenol removal by using Peroxidase enzyme extracted from Agricultural Waste
    Status: On-going
  3. HDR Student Name: Tan Kei Xian (PhD)
    Supervisors: Dr John Lau Sie Yon, Professor Dr Michael Danquah, Dr. Amandeep
    Project: Aptameric Formulation for Enhanced Cell-targeted Drug Delivery
    Status: On-going
  4. HDR Student Name: Ignatius Phang
    Supervisors: Dr Wong Kwong Soon, Dr Stephanie Chan Yen San, Dr John Lau Sie Yon
    Project: Investigation on shear strength and consolidation behavior of peat treated using microbial induced calcite precipitation
    Status: On-going
  5. HDR Student Name: Caleb Acquah (PhD)
    Supervisors: Professor Dr Michael Danquah, Dr John Lau Sie Yon,  Dr. Charles K.S. Moy, Dr. Clarence Ongkudon
    Project: Development of Aptamer-based polymeric Biosensors for Advanced Bioscreening
    Status: Graduating

Professional Associations

  • Chartered Engineer, Engineer Australia (EA) Chartered Area(s) of Practice Chemical Engineering & Environmental Engineering
  • Member of institute of Chemical Engineers (IChemE)
  • Member of American Chemical Society (ACS)
  • Member of Golden Key

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